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| # | Player | Team | Goals | Assists | G+A |
|---|---|---|---|---|---|
| 1 |  L. Messi |  Inter Miami | 13 | 7 | 20 |
| 2 |  P. Musa |  FC Dallas | 13 | 2 | 15 |
| 3 |  H. Cuypers |  Chicago Fire | 13 | 0 | 13 |
| 4 |  N. Fernández Mercau |  New York City FC | 13 | 3 | 16 |
| 5 |  P. Judd |  San Jose Earthquakes | 11 | 2 | 13 |
| 6 |  M. Ingvartsen |  San Diego | 11 | 2 | 13 |
| 7 |  K. Denkey |  FC Cincinnati | 11 | 2 | 13 |
| 8 |  T. Baribo |  DC United | 11 | 0 | 11 |
| 9 |  M. Ojeda |  Orlando City SC | 11 | 0 | 11 |
| 10 |  S. Surridge |  Nashville SC | 11 | 0 | 11 |
| 11 |  Guilherme |  Houston Dynamo | 10 | 5 | 15 |
| 12 |  D. Bouanga |  Los Angeles FC | 10 | 4 | 14 |
| 13 |  B. White |  Vancouver Whitecaps | 10 | 2 | 12 |
| 14 |  M. Iloski |  Philadelphia Union | 10 | 1 | 11 |
| 15 |  Evander | FC Cincinnati | 10 | 8 | 18 |
| 16 |  P. Owusu |  CF Montreal | 10 | 6 | 16 |
| 17 |  J. Hall |  New York Red Bulls | 9 | 3 | 12 |
| 18 |  K. Kelsy |  Portland Timbers | 9 | 2 | 11 |
| 19 |  Pep Biel |  Charlotte | 9 | 5 | 14 |
| 20 |  Rafael Navarro |  Colorado Rapids | 9 | 3 | 12 |
| 21 |  A. Dreyer | San Diego | 7 | 7 | 14 |
| 22 |  G. Berterame | Inter Miami | 7 | 4 | 11 |
| 23 |  P. Zinckernagel | Chicago Fire | 5 | 7 | 12 |
| 24 |  Son Heung-Min | Los Angeles FC | 4 | 8 | 12 |
| 25 |  M. Reus |  Los Angeles Galaxy | 4 | 6 | 10 |