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| # | Player | Team | Goals | Assists | G+A |
|---|---|---|---|---|---|
| 1 |  L. Messi |  Inter Miami | 26 | 13 | 39 |
| 2 |  P. Musa |  FC Dallas | 22 | 5 | 27 |
| 3 |  B. White |  Vancouver Whitecaps | 20 | 2 | 22 |
| 4 |  S. Surridge |  Nashville SC | 19 | 1 | 20 |
| 5 |  Rafael Navarro |  St. Louis City | 19 | 6 | 25 |
| 6 |  M. Iloski |  Philadelphia Union | 19 | 2 | 21 |
| 7 |  D. Bouanga |  Los Angeles FC | 18 | 5 | 23 |
| 8 |  K. Yeboah |  Minnesota United FC | 18 | 4 | 22 |
| 9 |  K. Denkey |  FC Cincinnati | 17 | 3 | 20 |
| 10 |  H. Mukhtar | Nashville SC | 16 | 7 | 23 |
| 11 |  P. Judd |  San Jose Earthquakes | 16 | 2 | 18 |
| 12 |  Guilherme |  Houston Dynamo | 16 | 8 | 24 |
| 13 |  N. Fernández Mercau |  New York City FC | 16 | 6 | 22 |
| 14 |  M. Ojeda |  Orlando City SC | 16 | 4 | 20 |
| 15 |  T. Baribo |  DC United | 16 | 1 | 17 |
| 16 |  I. Toklomati Giorno |  Charlotte | 15 | 5 | 20 |
| 17 |  L. Suárez | Inter Miami | 15 | 6 | 21 |
| 18 |  P. Owusu |  CF Montreal | 15 | 6 | 21 |
| 19 |  A. Griezmann | Orlando City SC | 14 | 7 | 21 |
| 20 |  S. Solans |  Real Salt Lake | 14 | 4 | 18 |
| 21 |  A. Dreyer |  San Diego | 14 | 12 | 26 |
| 22 |  Evander | FC Cincinnati | 13 | 11 | 24 |
| 23 |  Pep Biel | Charlotte | 12 | 8 | 20 |
| 24 |  M. Reus |  Los Angeles Galaxy | 8 | 12 | 20 |
| 25 |  P. Aaronson |  Colorado Rapids | 8 | 8 | 16 |