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| # | Club | Pld | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| Western Conference | ||||||||||
| 1 |  Vancouver Whitecaps | 25 | 15 | 4 | 6 | 56 | 23 | +33 | 49 | WLWLW |
| 2 |  Houston Dynamo | 26 | 13 | 5 | 8 | 34 | 30 | +4 | 44 | DLWDD |
| 3 |  St. Louis City | 26 | 12 | 8 | 6 | 45 | 36 | +9 | 44 | WWDWD |
| 4 |  FC Dallas | 26 | 12 | 8 | 6 | 49 | 42 | +7 | 44 | DWWWD |
| 5 |  San Jose Earthquakes | 26 | 12 | 6 | 8 | 46 | 38 | +8 | 42 | DWWDD |
| 6 |  Los Angeles FC | 27 | 11 | 8 | 8 | 43 | 29 | +14 | 41 | DLWDD |
| 7 |  Colorado Rapids | 26 | 11 | 3 | 12 | 36 | 35 | +1 | 36 | DWDLW |
| 8 |  Los Angeles Galaxy | 27 | 8 | 9 | 10 | 34 | 42 | -8 | 33 | WDLWL |
| 9 |  Portland Timbers | 26 | 9 | 5 | 12 | 47 | 48 | -1 | 32 | LLDWL |
| 10 |  San Diego | 26 | 8 | 7 | 11 | 44 | 44 | 0 | 31 | DLLLW |
| 11 |  Austin | 26 | 7 | 9 | 10 | 32 | 44 | -12 | 30 | DWDDW |
| 12 |  Real Salt Lake | 25 | 8 | 5 | 12 | 37 | 42 | -5 | 29 | LLLDL |
| 13 |  Seattle Sounders | 24 | 7 | 8 | 9 | 28 | 33 | -5 | 29 | DDDDD |
| 14 |  Minnesota United FC | 26 | 7 | 8 | 11 | 39 | 46 | -7 | 29 | LLLLD |
| 15 |  Sporting Kansas City | 25 | 5 | 3 | 17 | 29 | 63 | -34 | 18 | LWLLL |
| Eastern Conference | ||||||||||
| 1 |  Nashville SC | 26 | 17 | 6 | 3 | 53 | 21 | +32 | 57 | WDLDW |
| 2 |  New England Revolution | 26 | 14 | 4 | 8 | 45 | 33 | +12 | 46 | WWWLW |
| 3 |  Inter Miami | 26 | 12 | 10 | 4 | 63 | 48 | +15 | 46 | DDDDW |
| 4 |  Charlotte | 26 | 12 | 7 | 7 | 47 | 37 | +10 | 43 | WDWDW |
| 5 |  Chicago Fire | 25 | 11 | 6 | 8 | 45 | 38 | +7 | 39 | LLDDD |
| 6 |  Philadelphia Union | 26 | 10 | 6 | 10 | 50 | 42 | +8 | 36 | WWWWW |
| 7 |  Orlando City SC | 26 | 10 | 4 | 12 | 46 | 60 | -14 | 34 | LWWWD |
| 8 |  New York Red Bulls | 26 | 9 | 6 | 11 | 34 | 48 | -14 | 33 | WWLDL |
| 9 |  FC Cincinnati | 25 | 8 | 9 | 8 | 54 | 61 | -7 | 33 | DDLLD |
| 10 |  New York City FC | 26 | 8 | 8 | 10 | 39 | 34 | +5 | 32 | LWLDD |
| 11 |  DC United | 25 | 6 | 11 | 8 | 31 | 39 | -8 | 29 | LDWDL |
| 12 |  Toronto FC | 26 | 6 | 11 | 9 | 39 | 49 | -10 | 29 | LLWDD |
| 13 |  Columbus Crew | 26 | 7 | 5 | 14 | 37 | 42 | -5 | 26 | WLLWL |
| 14 |  Atlanta United FC | 26 | 7 | 5 | 14 | 30 | 43 | -13 | 26 | WDLDL |
| 15 |  CF Montreal | 26 | 5 | 6 | 15 | 31 | 53 | -22 | 21 | LLLLL |
| # | Team | Group | Pld | GD | Pts |
|---|---|---|---|---|---|
| 1 | Inter Miami | Eastern Conference | 26 | +15 | 46 |
| 2 | St. Louis City | Western Conference | 26 | +9 | 44 |